Endocrine Abstracts

Introduction: Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare disease inherited in an autosomal dominant pattern, caused by mutations in the MEN1 gene. The cardinal components of this syndrome are: primary hyperparathyroidism (PHPT), gastroenteropancreatic neuroendocrine tumors (NETs) and pituitary tumors.Aim: The aim of the study was to evaluate clinical features of MEN1 patients under care of two teritiary centers in Warsaw, Poland with special fo...

Acromegaly is a rare endocrine disorder caused by growth hormone (GH) secreting pituitary adenoma. The treatment of choice is transsphenoidal surgery. In patients with persistent disease after surgery medical therapy is recommended. First-line medical treatment include first generation long-acting somatostatin analogs: octreotide LAR and lanreotide autogel. Recently, pasireotide – a second generation somatostatin analog has been investigated in patients with acromegaly.</...

Introduction: Primary aldosteronism (PA) is one of the causes of hypertension. Blood aldosterone and the aldosterone/direct renin concentration (DRC) are routinely used as a screening test for PA.Aim of study: Whether it matters if aldosterone concentration is determined in serum or plasma samples?Material and methods: 145 healthy males, five females (blood donors) were investigated. In all subjects blood was collected into two tub...

Introduction: We present preliminary results of the treatment with DIAMOND system – novel method of therapy of type 2 diabetes (T2DM) associated with obesity, based on new technology – gastric contractility modulation (GCM).Material and methods: In 23 overweight/obese patients with T2DM enrolled into the polish arm of the multicenter, prospective, randomized study device modulating gastric contractility was implanted. We present data from nine ...

Introduction: Chromogranin A (CgA) is a main, nonspecific marker of neuroendocrine tumours (NET). There are various commercially assays for the measurement of CgA concentration in serum or plasma. These assays differ in analytical techniques (RIA, ELISA, CLIA), have different standardization, and use different antibodies which recognize different epitopes of CgA molecule.Aim of study: Our study was designed to confirm the noted earlier differences in CgA...

Histiocytosis is a disease caused by growth of histiocytes within one or more organs. Symptomatology may be very different: from isolated skin or bone lesions, by diabetes insipidus after life-threatening multisystem form. Diabetes insipidus as a symptom of pituitary can be observed many years before visibility of the changes in magnetic resonance imaging.A case of 59-year-old woman who has experienced diabetes insipidus with no other symptoms of hypopit...

Introduction: Thyroid diseases are frequent in acromegalic patients. We aimed to investigate thyroid function and morphology in a population of patients with de novo acromegaly.Materials and methods: We evaluated 32 patients newly diagnosed with acromegaly in a single medical center. We collected data on patient’s age, sex, duration of acromegaly symptoms, history of thyroid disease, laboratory tests results (serum GH, IGF1, TSH, fT4, fT3, ...

Hypophysitis is a rare clinical condition manifesting as pituitary dysfunction: hypopituitarism or diabetes insipidus (DI) and pituitary enlargement causing mass effect (headaches, visual disturbances) due to the inflammation of the pituitary gland. We conducted a retrospective analysis of medical records of patients diagnosed with hypophysitis in the Department of Endocrinology of the Bielanski Hospital from 2014 to 2019. Twenty-five patients were identified, which represents...

Background: Thyroid-stimulating hormone (TSH) expressing tumors are one of the rarest pituitary adenomas and comprises 0.5–2% of all cases. To our knowledge, only four cases of thyrotropinoma in a pregnant women have been reported up to date.Case presentation: We present a case of 24-year old women who reported to gynecologist due to secondary amenorrhea and severe headaches. Commissioned laboratory test showed, among others, prolactin 31.0 ng/ml a...

Background: Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare, autosomal dominant disease characterized by the coexistence of at least two of the following: primary hyperparathyroidism (PHPT), neuroendocrine tumors (NET) and pituitary tumors. The aim of the study was to evaluate epidemiology, clinical features and management of MEN1 patients in two referral centers in Warsaw, Poland.Material and Methods: Study group consisted of 52 patients, aged from...